Poststatin, a new inhibitor of prolyl endopeptidase. VII. N-cycloalkylamide analogues.

…, Y Muraoka, M Nagai, T Aoyagi, T Takeuchi

Index: Tsuda, Makoto; Muraoka, Yasuhiko; Nagai, Machiko; Aoyagi, Takaaki; Takeuchi, Tomio Journal of Antibiotics, 1996 , vol. 49, # 9 p. 909 - 920

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Citation Number: 9

Abstract

Poststatin analogues containing (S)-2-oxo-2-(2-pyrrolidinyl) acetyl moiety in P 1 were synthesized and examined for their inhibitory activity against prolyl endopeptidase and cathepsin B in vitro. Introduction of non-peptidyl cycloalkylamine component in P'1 was effective and P 3-acyl groups must be widely modifiable for prolyl endopeptidase inhibition. Acyl-L-phenylalanyl-(S)-2-oxo-2-(2-pyrrolidinyl) acetyl-cycloalkylamide type compounds ...

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