Helvetica chimica acta

Enantioselective Syntheses of α??Amino Acids from 10??(Aminosulfonyl)??2??bornyl Esters and Di (tert??butyl) Azodicarboxylate. Preliminary Communication

W Oppolzer, R Moretti

Index: Oppolzer, Wolfgang; Moretti, Robert Helvetica Chimica Acta, 1986 , vol. 69, p. 1923 - 1926

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Citation Number: 81

Abstract

Abstract Succesive treatment of chiral esters 1 with LiN (i-Pr) 2/Me 3 SiCl and di (tert-butyl) azodicarboxylate/TiCl 4/Ti (i-PrO) 4 gave N, N′-di [(tert-butoxy) carbonyl] hydrazino esters 9 which on deacylation, hydrogenolysis, transesterification, and acidic hydrolysis furnished (2S)-α-amino acids 6 in high enantiomeric purity with efficient recovery of the auxiliary alcohol 7.

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