Concise Synthesis of Bicyclic Aminals by Way of Catalytic Intramolecular CH Amination and Evaluation of Their Reactivity as Iminium Precursors

D Rodríguez-Lucena, M ST Morin…

Index: Rodriguez-Lucena, David; Morin, Marie S.T.; Compain, Philippe Letters in Organic Chemistry, 2011 , vol. 8, # 3 p. 155 - 162

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Abstract

The concise synthesis of fused bicyclic aminals by way of intramolecular rhodium-catalyzed CH amination is reported as well as the evaluation of their reactivity as iminium precursors. In contrast to the well-studied N, O-acetal systems, the aminals synthesized were found to be particularly stable under reaction conditions used for nucleophilic addition.

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Concise Synthesis of Bicyclic Aminals by Way of Catalytic Intramolecular CH Amination and Evaluation of Their Reactivity as Iminium Precursors

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