The Journal of Organic Chemistry

Synthesis of stereospecific deuterium-labeled homoserines and homoserine lactones

K Ramalingam, RW Woodard

Index: Ramalingam, Kondareddiar; Woodard, Ronald W. Journal of Organic Chemistry, 1988 , vol. 53, # 9 p. 1900 - 1903

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Citation Number: 37

Abstract

The syntheses of the stereospecific deuteriated derivatives (2S, 4R)-and (2S, 4S)-[4-* H] homoserine lactone hydrochlorides,(2S, 3R)-[3-'H]-and (2S, 3S)-[2, 3-2Hz] homoserine lactone hydrochlorides, and (2S, 3R, 4Z3)-[3, 4-2H2]-and (2S, 3S, 4S)-[2, 3, 4-* H,] homoserine lactone hydrochlorides as well as the homoserine derivatives themselves have been synthesized in eight simple steps from the appropriate aspartic acids via a route ...

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