Deuterated Analogs of verapamil and nifedipine. Synthesis and biological activity

…, PW Hake, B Børretzen, KH Holm, L Skattebøl

Index: Rampe; Hake; Borretzen; Holm; Skattebol European Journal of Medicinal Chemistry, 1993 , vol. 28, # 3 p. 259 - 263

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Citation Number: 28

Abstract

Abstract The preparations of various deuterium analogs of verapamil and nifedipine have been described. Deuterium is incorporated at specific positions in the molecules in 97% isotopic purity. The deuterated analogs 1d of verapamil and 2d of nifedipine lowered ...