Synthesis and conformation of n-trityl dipeptide derivatives

…, T Tsegenidis, P Cordopatis, D Theodoropoulos

Index: Matsoukas, J.; Tsegenidis, Th.; Cordopatis, P.; Theodoropoulos, D. Tetrahedron, 1984 , vol. 40, # 10 p. 1869 - 1872

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Citation Number: 4

Abstract

N-Tritylamino acids activated with DCC/HOBt, were coupled with various amino acid derivatives without racemization. The trityl group was split off quantitatively in 10% CCl3COOH monohydrate or CH2ClCOOH in CH2Cl2. Under these conditions detritylation of N-Trt-Trp-Gly-NH2 proceeds without formation of an oxindole derivative and side alkylation products, even in the absence of a scavenger. Dipeptide derivatives 1 and 2 exhibited ...