Synthesis and some pharmacological properties of [8-L-tryptophan] oxytocin

M Bodanszky, JC Tolle, J Seto…

Index: Bodanszky; Tolle; Seto; Sawyer Journal of medicinal chemistry, 1980 , vol. 23, # 11 p. 1259 - 1261

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Citation Number: 5

Abstract

Condensation of (tert-butyloxycarbony1) tccinoic acid with L-prolyl-L-tryptophylglycinamide produced the Boc derivative of a nonapeptide (disulfide) which on deprotection afforded [8-~- tryptophan] oxytocin. In assays on the rat uterus in vitro and in vivo the new analogue acts as both an agonist and an antagonist. The duration of both actions is prolonged.

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