Systematic Studies using 2??(1??Adamantylethynyl) pyrimidine??5??carbaldehyde as a Starting Material in Soai's Asymmetric Autocatalysis

M Busch, M Schlageter, D Weingand…

Index: Busch, Mark; Schlageter, Martin; Weingand, Daniel; Gehring, Timo Chemistry - A European Journal, 2009 , vol. 15, # 33 p. 8251 - 8258

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Citation Number: 18

Abstract

Abstract Herein, we present a new substrate for the Soai reaction, which has an adamantylethynyl residue (1 g) and exhibits asymmetric autocatalysis, yielding products with enantiomeric excesses above 99%. For the first time, all reactions were performed on a parallel synthesizer system to ensure identical reaction conditions. A detailed systematic study of reaction parameters was performed and we report the highest enhancements of ...

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