Remarkable Enantioselective a-Amination in 1-Phenyl-2-(N-alkylamino)-1-propanol

…, V Murugesan, T Prakasam, PS Srinivasan…

Index: Kumar, Borkatte N. Hitesh; Murugesan, Velayutham; Prakasam, Tangirala; Srinivasan, Pathangi S.; Ramana, Devalla V. Chirality, 2012 , vol. 24, # 3 p. 262 - 270

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Abstract

Abstract (1R, 2R)-1-Phenyl-1-alkyl/arylamino-2-(N-alkylamino) propane hydrochloride salts have been synthesized with high degree of enantiomeric purity from (1S, 2R)-(+)-1-phenyl-2- (N-alkylamino)-1-propanol through the corresponding chloro derivatives. This reaction sequence involves three inversions with overall inversion of configuration at C-1. Chirality, 2012.© 2012 Wiley Periodicals, Inc.