Journal of Molecular Catalysis A: Chemical

Varying the ratio of formic acid to triethylamine impacts on asymmetric transfer hydrogenation of ketones

X Zhou, X Wu, B Yang, J Xiao

Index: Zhou, Xiaowei; Wu, Xiaofeng; Yang, Bolun; Xiao, Jianliang Journal of Molecular Catalysis A: Chemical, 2012 , vol. 357, p. 133 - 140

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Citation Number: 24

Abstract

Asymmetric transfer hydrogenation (ATH) is frequently carried out in the azeotropic mixture of formic acid (F) and triethylamine (T), where the F/T molar ratio is 2.5. This study shows that the F/T ratio affects both the reduction rate and enantioselectivity, with the optimum ratio being 0.2 in the ATH of ketones with the Ru-TsDPEN catalyst. Under such conditions, a range of substrates have been reduced, affording high yields and good to excellent ...

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