The Journal of Organic Chemistry

Preparation of t-Butyl Esters of Free Amino Acids1

R Roeske

Index: Roeske,R. Journal of Organic Chemistry, 1963 , vol. 28, p. 1251 - 1253

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Citation Number: 131

Abstract

The t-butyl esters of amino acids are useful carboxylprotecting groups in peptide synthesis because they are cleaved readily by acids. The esters have been prepared from N-acylated amino acids by reaction with isobutene,* or t-butyl acetate3 and by conversion of the a- chloro-t-butyl esters to the amino esters via the azide, 4 a process which yields racemic esters. Some amino esters have been prepared from the free amino acids by reaction with ...