Preparation of N-arylpiperazines and other N-aryl compounds from aryl bromides as scaffolds of bioactive compounds
M Romero, Y Harrak, J Basset, L Ginet, P Constans…
Index: Romero; Harrak; Basset; Ginet; Constans; Pujol Tetrahedron, 2006 , vol. 62, # 38 p. 9010 - 9016
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Citation Number: 26
Abstract
Aryl bromides are coupled with N-compounds to give the corresponding arylamines in the presence of a palladium catalyst, a suitable ligand, and a weak base. The catalysts perform well for a large number of different starting material combinations at 100–150° C with drops of toluene or without solvent, and with low catalyst levels (0.12 mol% Pd). The low catalyst amount makes the process environment friendly.
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