Tetrahedron: Asymmetry

A highly enantioselective organocatalyst for the Michael addition of cyclic ketones to nitroolefins

MK Zhu, LF Cun, AQ Mi, YZ Jiang, LZ Gong

Index: Zhu, Ming-Kui; Cun, Lin-Feng; Mi, Ai-Qiao; Jiang, Yao-Zhong; Gong, Liu-Zhu Tetrahedron Asymmetry, 2006 , vol. 17, # 4 p. 491 - 493

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Citation Number: 67

Abstract

Organocatalyzed asymmetric synthesis has received great attention due to it being environmentally benign and fundamentally interesting. 1 Asymmetric Michael addition of nucleophiles to nitroolefins generates very useful chiral building blocks for organic synthesis. 2 The development of efficient organocatalysts for this reaction is, therefore, of fundamental importance. Recently, a highly enantioselective Michael reaction of malonates to nitroolefins has been reported, using chiral thiourea ...