The power of visual imagery in drug design. Isopavines as a new class of morphinomimetics and their human opioid receptor binding activity

…, S Parthasarathy, M Mauduit, K Payza

Index: Hanessian, Stephen; Parthasarathy, Saravanan; Mauduit, Marc; Payza, Kemal Journal of Medicinal Chemistry, 2003 , vol. 46, # 1 p. 34 - 48

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Citation Number: 26

Abstract

The importance of visual imagery and relational thinking manifests itself in a heuristic approach to the design and synthesis of potential morphinomimetics as agonists of the human μ-receptor. The well-known class of alkaloids represented by the isopavine nucleus has a topological resemblance to the morphine skeleton, especially when viewed in a particular way. Enantiopure isopavines can be readily obtained from a 1, 2 Stevens ...