Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa

…, R Brenk, MS Scherman, M McNeil, M Rejzek…

Index: Alphey, Magnus S.; Pirrie, Lisa; Torrie, Leah S.; Boulkeroua, Wassila Abdelli; Gardiner, Mary; Sarkar, Aurijit; Maringer, Marko; Oehlmann, Wulf; Brenk, Ruth; Scherman, Michael S.; McNeil, Michael; Rejzek, Martin; Field, Robert A.; Singh, Mahavir; Gray, David; Westwood, Nicholas J.; Naismith, James H. ACS Chemical Biology, 2013 , vol. 8, # 2 p. 387 - 396

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Citation Number: 10

Abstract

Glucose-1-phosphate thymidylyltransferase (RmlA) catalyzes the condensation of glucose-1- phosphate (G1P) with deoxy-thymidine triphosphate (dTTP) to yield dTDP-d-glucose and pyrophosphate. This is the first step in the l-rhamnose biosynthetic pathway. l-Rhamnose is an important component of the cell wall of many microorganisms, including Mycobacterium tuberculosis and Pseudomonas aeruginosa. Here we describe the first nanomolar ...