Synthesis and binding activity of endomorphin-1 analogues containing β-amino acids

…, L Gentilucci, P Melchiorre, S Spampinato

Index: Cardillo, Giuliana; Gentilucci, Luca; Melchiorre, Paolo; Spampinato, Santi Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2755 - 2758

Full Text: HTML

Citation Number: 61

Abstract

Endomorphin-1 (Tyr-Pro-Trp-PheNH2) has been proposed as the most potent endogenous ligand of the μ-opioid receptors. In this paper, we describe the synthesis of some endomorphin-1 based tetrapeptides in which a residue of the sequence Tyr-Pro-Trp- PheNH2 is replaced by the corresponding β-isomer. These novel peptides showed different affinities for the opioid receptors labeled with [3H]-DAMGO in rat brain membranes, ...

Related Articles:

Parallel synthesis of homochiral β-amino acids

[Davies, Stephen G.; Mulvaney, Andrew W.; Russell, Angela J.; Smith, Andrew D. Tetrahedron Asymmetry, 2007 , vol. 18, # 13 p. 1554 - 1566]

Parallel synthesis of homochiral β-amino acids

[Davies, Stephen G.; Mulvaney, Andrew W.; Russell, Angela J.; Smith, Andrew D. Tetrahedron Asymmetry, 2007 , vol. 18, # 13 p. 1554 - 1566]

Parallel synthesis of homochiral β-amino acids

[Davies, Stephen G.; Mulvaney, Andrew W.; Russell, Angela J.; Smith, Andrew D. Tetrahedron Asymmetry, 2007 , vol. 18, # 13 p. 1554 - 1566]

Parallel synthesis of homochiral β-amino acids

[Davies, Stephen G.; Mulvaney, Andrew W.; Russell, Angela J.; Smith, Andrew D. Tetrahedron Asymmetry, 2007 , vol. 18, # 13 p. 1554 - 1566]

More Articles...