Synthesis of ring-oxidized retinoids as substrates of mouse class I alcohol dehydrogenase (ADH1)

M Domínguez, R Alvarez, S Martras, J Farrés…

Index: Dominguez, Marta; Alvarez, Rosana; Martras, Silvia; Farres, Jaume; Pares, Xavier; De Lera, Angel R. Organic and Biomolecular Chemistry, 2004 , vol. 2, # 22 p. 3368 - 3373

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Citation Number: 14

Abstract

Biochemical modifications of the prohormone vitamin A (retinol, 1) 1 generate a diversity of metabolites that play key roles in fundamental physiological processes, such as vision, 2 cell differentiation, cell proliferation and apoptosis, development and immunity. 3 Many of these cellular processes are mediated by all-trans-retinoic acid and its 9-cis stereoisomer, which bind to and activate the retinoid receptors (RARs, RXRs), members of a nuclear receptor superfamily. ...