Synthesis of polyenes. III. A new synthesis of diethylstilbestrol

MS Kharasch, M Kleiman

Index: Kharasch; Kleiman Journal of the American Chemical Society, 1943 , vol. 65, p. 11,14

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Citation Number: 25

Abstract

Diethylstilbestrol dimethyl ether ___f Diethylalcohol stilbestrol chloride and 0-methylallyl chloride to he~ atriene~'and 2, 5dimethylhe~ atriene,~~ respectively, under the influence of sodamide in liquid ammonia has. been studied exhaustively. The hypothesis evolved to account for these reactions suggested that a molecule such as anethole hydrobromide should react with sodamide or potassium amide to yield the products shown below. ...