1-((S)-2-Aminopropyl)-1 H-indazol-6-ol: A Potent Peripherally Acting 5-HT2 Receptor Agonist with Ocular Hypotensive Activity

JA May, AP Dantanarayana, PW Zinke…

Index: May, Jesse A.; Dantanarayana, Anura P.; Zinke, Paul W.; McLaughlin, Marsha A.; Sharif, Najam A. Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 318 - 328

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Citation Number: 46

Abstract

Serotonin 5-HT2 receptor agonists have been identified as a potential new class of agents for the treatment of ocular hypertension and glaucoma. The initially reported tryptamine analogues displayed either poor solution stability, potent central nervous system activity, or both of these undesirable characteristics and were unacceptable for clinical evaluation. A series of 1-(2-aminopropyl)-1 H-indazole analogues was synthesized and evaluated for ...