Synthesis of some new fluorine containing thiadiazolotriazinones as potential antibacterial agents

BS Holla, KS Bhat, NS Shetty

Index: Holla, B. Shivarama; Bhat, K. Subrahmanya; Shetty, N. Suchetha Phosphorus, Sulfur and Silicon and the Related Elements, 2003 , vol. 178, # 10 p. 2193 - 2199

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Citation Number: 5

Abstract

2, 4-dichloro-5-fluorophenyl, 4-fluoro-3-(Phenoxy) phenyl, 4-fluorophen-yl groups are known pharmacophores and can be used in the synthesis of new biologically active molecules. Therefore, 4-amino-6-arylmethyl-3-mercapto-1, 2, 4-triazin5 (4H)-ones 1 are condensed with 3-phenoxy-4-fluoro-benzoic acid, 2, 4-dichloro-5-fluorobenzoic acid, and 4-fluorobenzoic acid 2 to give 7-substituted-3-arylmethyl-4H-1, 3, 4-thiadiazolo [2, 3-c]-1, 2, 4-triazin-4- ...