Fairly Marked Enantioselectivity for the Hydrolysis of Amino Acid Esters by Chemically Modified Enzymes1

…, K Shimada, J Okai, K Goto, Y Matsumoto…

Index: Yano, Yoshihiro; Shimada, Kenji; Okai, Jiro; Goto, Koichi; Matsumoto, Yoko; Ueoka, Ryuichi Journal of Organic Chemistry, 2003 , vol. 68, # 4 p. 1314 - 1318

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Citation Number: 6

Abstract

The hydrolysis (deacylation) of enantiomeric substrates by the chemically modified enzymes decanoyl-α-chymotrypsin and decanoyl-trypsin was studied. Reaction activity for decanoyl-α- chymotrypsin was lower than that for the native enzyme, although intriguingly the enantioselectivity was markedly enhanced as compared with the native enzyme. In particular, the apparently complete enantioselective catalysis was attained for the ...