Synthesis of oxindole derivatives from N??alkenyl??o??chloroanilides with zero??valent nickel complex

L Canoira, JG Rodriguez

Index: Canoira, L.; Rodriguez, J. G. Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1511 - 1518

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Citation Number: 32

Abstract

Abstract Oxindole derivatives have been obtained from N-alkenyl-o-chloroanilides by reaction with tetrakis (triphenylphosphine) nickel (0) in toluene as solvent in good yields. A detailed analysis of all the products of the reaction allows to confirm the postulated mechanism of the cyclization reaction. The o-chloroanilides of the 3-cyclohexenylacetic acid fails in the cyclization reaction, since the torsional hindrance seems to avoid that the ...