Bioorganic & medicinal chemistry letters

A polymer-supported [1, 3, 2] oxazaphospholidine for the conversion of isothiocyanates to isocyanides and their subsequent use in an Ugi reaction

SV Ley, SJ Taylor

Index: Ley, Steven V; Taylor, Stephen J Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 14 p. 1813 - 1816

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Citation Number: 60

Abstract

The design and synthesis of a new polymer supported reagent for the clean conversion of isothiocyanates to isocyanides under microwave conditions was accomplished. The structurally diverse isocyanides generated were used in an Ugi 3CC, allowing the rapid generation of 2-isoindolinone-7-carboxamide analogues.

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