Journal of the American Chemical Society

Hydroxy-1, 2, 5-thiadiazoles. I. A Novel Route from Potassium Cyanide and Sulfur Dioxide

JM Ross, WC Smith

Index: Ross,J.M.; Smith,W.C. Journal of the American Chemical Society, 1964 , vol. 86, p. 2861 - 2868

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Citation Number: 19

Abstract

3-Cyan0-4-hydroxy-1.2, Bthiadiazole has been obtained from the reaction of potassium cyanide and sulfur dioxide at 25-85'in the absence of hydroxylic solvents. The structure was elucidated by degradation to diethylaminoacetamide and to N-sulfamoyloxamic acid dipotassium salt, and by independent synthesis from isonitrosocyanoacetamide and sulfur dichloride. Various 3-hydroxy-1, 2, 5-thiadiazole derivatives were prepared including ...