Synthesis of polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth

M Thévenin, S Thoret, P Grellier, J Dubois

Index: Thevenin, Marion; Thoret, Sylviane; Grellier, Philippe; Dubois, Joelle Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 4885 - 4892

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Citation Number: 16

Abstract

Abstract A series of polysubstituted benzofuran derivatives was easily and rapidly prepared using a tandem Sonogashira coupling/cyclization reaction. Subsequent acylation afforded a small library of 39 new compounds that were assayed in cellulo on Plasmodium falciparum and Trypanosoma brucei parasites. Some of them exhibited good inhibitory activity on T. brucei proliferation.

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