Structure-Activity Relationship of 2-[[(2-Pyridyl) methyl] thio]-1 H-benzimidazoles as Anti Helicobacter pylori Agents in Vitro and Evaluation of their in Vivo Efficacy

…, M Swanson, V Shcherbuchin, H Larsson…

Index: Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788

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Citation Number: 65

Abstract

A relationship between the structure of 21 2-[[(2-pyridyl) methyl] thio]-1 H-benzimidazoles (6) and their anti He l icobacter py l ori activity expressed as minimum bactericidal concentration (MBC) values is described. Observed MBCs ranged from 256 to 1 μg/mL. The structure- activity relationship (SAR) showed that larger and more lipophilic compounds, especially compounds with such substituents in the 4-position of the pyridyl moiety, generally had ...