Tetrahedron

Nickel-phosphine complex-catalyzed Grignard coupling—II: Grignard coupling of heterocyclic compounds

K Tamao, S Kodama, I Nakajima, M Kumada, A Minato…

Index: Tamao, K.; Kodama, S.; Nakajima, I.; Kumada, M.; Minato, A.; Suzuki, K. Tetrahedron, 1982 , vol. 38, # 22 p. 3347 - 3354

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Citation Number: 622

Abstract

A general, versatile method for alkylation and arylation of haloheterocyclic compounds is reported. In the presence of a catalytic quantity of [NiCl2 (dppp)], where dppp stands for Ph2P (CH2) 3PPh2, bromothiophenes, halopyridines, haloquinoline, and haloisoquinolines reacted with alkyl and aryl Grignard reagents at room temperature or at ether refluxing temperature to give the cross-coupling products. The coupling reaction has been applied ...