RSC Advances

C–N bond formation via Cu-catalyzed cross-coupling with boronic acids leading to methyl carbazole-3-carboxylate: synthesis of carbazole alkaloids

…, KR Reddy, S Aravinda, RA Vishwakarma, P Das

Index: Rasheed, Sk.; Rao, D. Nageswar; Reddy, K. Ranjith; Aravinda; Vishwakarma, Ram A.; Das, Parthasarathi RSC Advances, 2014 , vol. 4, # 10 p. 4960 - 4969

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Citation Number: 7

Abstract

Copper promoted N-arylation of methyl 4-amino-3-iodobenzoate with boronic acids followed by Pd-catalyzed intramolecular C–H arylation provides an efficient route to methyl carbazole- 3-carboxylate derivatives. This methodology was implemented in the synthesis of naturally occurring carbazole alkaloids clausine C, clausine H, clausine L, clausenalene, glycozoline, glycozolidine, glycozolidal and sansoakamine.

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