Design, synthesis and the effect of 1, 2, 3-triazole sialylmimetic neoglycoconjugates on Trypanosoma cruzi and its cell surface trans-sialidase

VL Campo, R Sesti-Costa, ZA Carneiro, JS Silva…

Index: Campo, Vanessa L.; Sesti-Costa, Renata; Carneiro, Zumira A.; Silva, Joao S.; Schenkman, Sergio; Carvalho, Ivone Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 1 p. 145 - 156

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Citation Number: 34

Abstract

This work describes the synthesis of a series of sialylmimetic neoglycoconjugates represented by 1, 4-disubstituted 1, 2, 3-triazole-sialic acid derivatives containing galactose modified at either C-1 or C-6 positions, glucose or gulose at C-3 position, and by the amino acid derivative 1, 2, 3-triazole fused threonine-3-O-galactose as potential TcTS inhibitors and anti-trypanosomal agents. This series was obtained by Cu (I)-catalysed azide–alkyne ...