Highly Selective Palladium??Catalysed Aminocarbonylation of Aryl Iodides using a Bulky Diphosphine Ligand

V de la Fuente, C Godard, C Claver…

Index: De La Fuente, Veronica; Godard, Cyril; Claver, Carmen; Castillon, Sergio Advanced Synthesis and Catalysis, 2012 , vol. 354, # 10 p. 1971 - 1979

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Abstract

Abstract An efficient methodology for the synthesis of amides via palladium-catalysed aminocarbonylation of aryl iodides is reported using the bulky cis-1, 2-bis [(di-tert- butylphosphino) methyl] cyclohexane ligand under atmospheric pressure of carbon monoxide. Excellent conversions (up to 99%) and chemoselectivities (up to 99%) were obtained for a range of aryl iodides and amine nucleophiles. The effect of the substituents ...

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