Development of a practical and reliable synthesis of laquinimod

J Wennerberg, A Björk, T Fristedt…

Index: Organic Process Research and Development, , vol. 11, # 4 p. 674 - 680

Full Text: HTML

Citation Number: 16

Abstract

... Organic Process Research & Development. ... in the two-step procedure is more than 10% higher (82%) than the yield in the corresponding one-pot procedure (71 ... 2b,6 Toluene and the formed alcohol are distilled off during the process, and the distillation rate greatly influences the ...

Related Articles:

3-(1, 1-Dioxo-2 H-(1, 2, 4)-benzothiadiazin-3-yl)-4-hydroxy-2 (1 H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase

[Tedesco, Rosanna; Shaw, Antony N.; Bambal, Ramesh; Chai, Deping; Concha, Nestor O.; Darcy, Michael G.; Dhanak, Dashyant; Fitch, Duke M.; Gates, Adam; Gerhardt, Warren G.; Halegoua, Dina L.; Han, Chao; Hofmann, Glenn A.; Johnston, Victor K.; Kaura, Arun C.; Liu, Nannan; Keenan, Richard M.; Lin-Goerke, Juili; Sarisky, Robert T.; Wiggall, Kenneth J.; Zimmerman, Michael N.; Duffy, Kevin J. Journal of Medicinal Chemistry, 2006 , vol. 49, # 3 p. 971 - 983]

More Articles...