Direct asymmetric intermolecular aldol reactions catalyzed by amino acids and small peptides

…, W Zou, P Dziedzic, I Ibrahem, E Reyes…

Index: Cordova, Armando; Zou, Weibiao; Dziedzic, Pawel; Ibrahem, Ismail; Reyes, Efraim; Xu, Yongmei Chemistry - A European Journal, 2006 , vol. 12, # 20 p. 5383 - 5397

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Citation Number: 223

Abstract

Abstract In nature there are at least nineteen different acyclic amino acids that act as the building blocks of polypeptides and proteins with different functions. Here we report that α- amino acids, β-amino acids, and chiral amines containing primary amine functions catalyze direct asymmetric intermolecular aldol reactions with high enantioselectivities. Moreover, the amino acids can be combined into highly modular natural and unusual small peptides that ...

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