New amido derivatives as potential BKCa potassium channel activators. XI

V Calderone, FL Fiamingo, G Amato, I Giorgi…

Index: Calderone, Vincenzo; Fiamingo, Francesca Lidia; Amato, Gabriella; Giorgi, Irene; Livi, Oreste; Martelli, Alma; Martinotti, Enrica European Journal of Medicinal Chemistry, 2008 , vol. 43, # 4 p. 792 - 799

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Abstract

The vasorelaxing effects of exogenous activators of large-conductance calcium-activated potassium channels (BK channels) can furnish the pharmacological rational basis for the treatment of hypertension and/or other diseases related with an impaired contractility of vessels. Since in previous works some benzanilide derivatives showed BK channel-induced vasorelaxing activity, in this paper we have taken into consideration the introduction of ...