Tetrahedron

Carbon–carbon bond formations at the benzylic positions of N-benzylxanthone imines and N-benzyldi-1-naphthyl ketone imine

T Niwa, T Suehiro, H Yorimitsu, K Oshima

Index: Niwa, Takashi; Suehiro, Takafumi; Yorimitsu, Hideki; Oshima, Koichiro Tetrahedron, 2009 , vol. 65, # 26 p. 5125 - 5131

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Citation Number: 18

Abstract

Two N-benzyl imines are designed to allow for carbon–carbon bond formations at the aminated benzylic positions. Direct benzylic arylation reactions of N-benzylxanthone imine with aryl chlorides proceed under palladium catalysis in the presence of cesium hydroxide, yielding the corresponding benzhydrylamine derivatives. Alkylation reactions of N-benzyldi- 1-naphthyl ketone imine with alkyl halides in the presence of potassium tert-butoxide ...