Tetrahedron

An efficient synthesis of JSTX-3, a potent neurotoxin of Joro spider (Nephila clavata)

M Matsushita, T Kanemura, S Hatakeyama, H Irie…

Index: Matsushita, Masayuki; Kanemura, Takanori; Hatakeyama, Susumi; Irie, Hiroshi; Toki, Takashi; Miyashita, Masaaki Tetrahedron, 1995 , vol. 51, # 39 p. 10687 - 10698

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Citation Number: 12

Abstract

JSTX-3 (Joro spider toxin-3)(1), a potent neurotoxin isolated from Joro spider (Nephila clavata), has been efficiently synthesized starting from 5-azido-lN-Boc-pentylamine (11) via the convergent synthetic strategy in which the characteristic polyamine components of the toxin were effectively constructed by the use of two key azide intermediates.

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