Sonogashira cross-coupling reactions with heteroaryl halides in the presence of a tetraphosphine–palladium catalyst

M Feuerstein, H Doucet, M Santelli

Index: Feuerstein, Marie; Doucet, Henri; Santelli, Maurice Tetrahedron Letters, 2005 , vol. 46, # 10 p. 1717 - 1720

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Citation Number: 58

Abstract

Heteroaryl halides undergoes cross-couplings with alkynes in good yields in the presence of [PdCl (C3H5)] 2/cis, cis, cis-1, 2, 3, 4-tetrakis (diphenylphosphinomethyl) cyclopentane as catalyst. A variety of heteroaryl halides such as pyridines, quinolines, a pyrimidine, an indole, a thiophene, or a thiazole have been used successfully. The reaction also tolerates several alkynes such as phenylacetylene and a range of alk-1-ynols. Furthermore, this ...