Identification of novel matrix metalloproteinase inhibitors by screening of phenol fragments library

…, A Laghezza, F Loiodice, P Tortorella

Index: Rubino, Maria Teresa; Maggi, Dariana; Laghezza, Antonio; Loiodice, Fulvio; Tortorella, Paolo Archiv der Pharmazie, 2011 , vol. 344, # 9 p. 557 - 563

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Citation Number: 11

Abstract

Abstract In the last 20 years, a great variety of synthetic, low molecular weight MMP inhibitors (MMPIs) have been synthesized and tested, although none has reached clinical utility. Exploration of novel ZBGs and development of non-hydroxamate MMPI has become a focus in current research. It's well-known that polyphenols can produce beneficial effects on human health by their antioxidant properties as well as they have the ability to block ...