Hydrates of quaternary ammonium aldehydes as potential reactivators of Sarin-inhibited acetylcholinesterase

…, F Liška, J Patočka, F Riedl, K Ševčíková

Index: Cabal, Jiri; Hampl, Frantisek; Liska, Frantisek; Patocka, Jiri; Riedl, Frantisek; Sevcikova, Katerina Collection of Czechoslovak Chemical Communications, 1998 , vol. 63, # 7 p. 1021 - 1030

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Citation Number: 9

Abstract

Abstract Synthesis of 2-(5a), 3-(5b) and 4-formyl-1-methylpyridinium iodides (5c) and (2, 2- dihydroxyethyl) trimethylammonium chloride (6a) is described. In aqueous solution aldehydes 5 exist predominantly as hydrates-geminal diols 7. The ability of the geminal diols 6a and 7 to reactivate acetylcholinesterase inhibited by isopropyl methylfluorophosphonate (Sarin) was tested in vitro. Although compounds 6a and 7 exhibit an affinity towards the ...