Synthesis of substituted 10, 11??dihydro??5H??dibenz [b, f] azepines; key synthons in syntheses of pharmaceutically active compounds

TK Jørgensen, KE Andersen, J Lau…

Index: Jorgensen, Tine Krogh; Andersen, Knud Erik; Lau, Jesper; Madsen, Peter; Huusfeldt, Per Olaf Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 1 p. 57 - 64

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Citation Number: 8

Abstract

Abstract Substituted 10, 11-dihydro-5H-dibenz [b, f] azepines are key synthons in the syntheses of a number of pharmaceutically active compounds such as imipramine, chlorimipramine, and desimipramine analogues. A facile synthesis of substituted 10, 11- dihydro-5H-dibenz [b, f] azepines is described, starting out from com mercially available 2- bromotoluenes or 2-nitrotoluenes. Initial α-bromination with N-bromosuccinimide and ...