Synthesis and Metabolism of 6-Hydroxycatecholamines*

JW Daly, J Benigni, R Minnis, Y Kanaoka, B Witkop

Index: Daly et al. Biochemistry, 1965 , vol. 4, p. 2513

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Citation Number: 15

Abstract

ABSTRACT: The following 6-hydroxycatecholamines (2, 4, 5-trihydroxyphenethylamines or- phenethanolamines), potential metabolites of catecholamines, were synthesized (Charts 1- 111): 3-0-methyl-6-hydroxydopamine, 6-hydroxynorepinephrine, 3-0-methyl-6- hydroxynorepinephrine, 6-hydroxyepinephrine, and 3-0-methyl-6-hydroxyepinephrine. Enzymatic 0-methylation with catechol 0-methyltransferase with S-adenosylmethionine-lT ...