A new and convenient synthesis of 1. ALPHA., 25-dihydroxyvitamin D2 and its 24R-epimer.
M Tsuji, S Yokoyama, Y Tachibana
Index: Tsuji; Yokoyama; Tachibana Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 10 p. 3132 - 3137
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Citation Number: 25
Abstract
1α, 25-Dihydroxyvitamin D 2 (1a) was synthesized by irradiation and subsequent thermal isomerization of (22E)-5, 7, 22-ergostatriene-1α, 3β, 25-triol (16a). The triol 16a was obtained via 22-oxo-5α, 8α-(4-phenyl-3, 5-dioxo-1, 2, 4-triazolidine-1, 2-diyl)-23, 24-dinor-6- cholene-1α, 3β-diyl diacetate (12) starting from (22E)-5, 7, 22-ergostatriene-1α, 3β-diyl diacetate (10), a precursor of 1α-hydroxyvitamin D 2. Introduction of the new side chain ...
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