Synthesis

Synthesis of 5-Fluoro-1, 3-dioxin-4-ones: Novel Alternatives to α-Fluorinated Acyl Ketenes

T Iwaoka, T Murohashi, M Sato, C Kaneko

Index: Iwaoka; Murohashi; Sato; Kaneko Synthesis, 1992 , # 10 p. 977 - 981

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Citation Number: 10

Abstract

Fluorination of 5, 6-unsubstituted 1, 3-dioxin-4-ones and their 6-substituted derivatives by molecular fluorine followed by treatment with an appropriate organic base affords the title compounds, which can be converted either into heterocyclic compounds or into acylacetic acid derivatives having a fluorine atom. 1, 3-Dioxin-4-ones A have been used as versatile building blocks for organic synthesis3 due to their ready ring opening to give either acyl ...