Estrogenic and antiestrogenic activity of monophenolic analogs of tamoxifen,[(Z)-2-[p-(1, 2-diphenyl-1-butenyl) phenoxy]-N, N-dimethylethylamine]

PC Ruenitz, JR Bagley, CM Mokler

Index: Ruenitz, Peter C.; Bagley, Jerome R.; Mokler, Corwin M. Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1056 - 1060

Full Text: HTML

Citation Number: 59

Abstract

Five hydroxylated analogues of tamoxifen [1,(2)-2-[p-(1, 2-diphenyl-l-butenyl) phenoxy]-~,~- dimethylethylamine] and its geometric isomer were prepared by reaction of protected hydroxy-a-ethyldeoxybenzoins with 4-[2-(di-methylamino) ethoxy] phenylmagnesium bromide, followed by acid-catalyzed dehydration-deprotection and chromatographic separation of isomer mixtures. Estrogen receptor binding affinity and estrogenic and ...