Improved synthesis of vitamin K1

…, ZM Zong, XY Wei, GZ Tu, L Xu, LT He

Index: Ji, Ya-Fei; Zong, Zhi-Min; Wei, Xian-Yong; Tu, Guang-Zhong; Xu, Li; He, Lin-Tao Synthetic Communications, 2003 , vol. 33, # 5 p. 763 - 772

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Citation Number: 6

Abstract

Abstract With (E/Z)-isomeric phytyl halides as side-chain materials, vitamin K 1 is synthesized via a Diels–Alder reaction to activate the free bridgehead hydrogen of 3 for the alkylation and a retro-Diels–Alder reaction to eliminate cyclopentadiene from 2 in a high