An In Vitro Assay for Evaluation of Small??Molecule Inhibitors of Cholesterol Absorption

L Kværnø, T Ritter, M Werder, H Hauser…

Index: Kvaerno, Lisbet; Ritter, Tobias; Werder, Moritz; Hauser, Helmut; Carreira, Erick M. Angewandte Chemie - International Edition, 2004 , vol. 43, # 35 p. 4653 - 4656

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Citation Number: 29

Abstract

Cardiovascular disease is the leading cause of death in the Western industrialized world and claims more lives than the next four causes combined.[1] A major risk factor for this disease is elevated cholesterol levels.[2, 3] The current predominant therapy prescribes the use of statins, which lead to inhibition of cholesterol biosynthesis in the liver.[3, 4] However, half of all patients undergoing current lipid-lowering treatments fail to reach their ...