Journal of the American Chemical Society

The Synthesis of Labile Hydroxytryptophan Metabolites1

A Ek, B Witkop

Index: Ek; Witkop Journal of the American Chemical Society, 1954 , vol. 76, p. 5579,5584

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Citation Number: 52

Abstract

New labile metabolites derived from tryptophan and bearing oxygen functions in positions 5 and 7 have been prepared and correlated with regard to their actual and potential significance in various biological systems (Table I). By modifications of the Nenitzescu-van der Lee synthesis 5-and 7-hydroxytryptophan,-tryptamine and-(hetero) auxin have been prepared in good yield. The availability of these synthetic substances made possible ...