Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer

…, GA Bebernitz, DJ Cook, LA Dakin, TL Deegan…

Index: Scott, David A.; Aquila, Brian M.; Bebernitz, Geraldine A.; Cook, Donald J.; Dakin, Les A.; Deegan, Tracy L.; Hattersley, Maureen M.; Ioannidis, Stephanos; Lyne, Paul D.; Omer, Charles A.; Ye, Minwei; Zheng, XiaoLan Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 17 p. 4794 - 4797

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Citation Number: 26

Abstract

The bisamide class of kinase inhibitors was identified as being active against CSF-1R. The synthesis and SAR of pyridyl and thiazolyl bisamides are reported, along with the pharmacokinetic properties and in vivo activity of selected examples.