Conception and Evolution of Stereocontrolled Strategies toward Functionalized 8-Aryloctanoic Acids Related to the Total Synthesis of Aliskiren

S Hanessian, E Chénard, S Guesné…

Index: Hanessian, Stephen; Chenard, Etienne Organic Letters, 2012 , vol. 14, # 12 p. 3222 - 3225

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Citation Number: 6

Abstract

A detailed account is given describing the approaches used toward the total synthesis of aliskiren. In particular, ring-closing metathesis with the Hoveyda–Grubbs catalyst accelerates the formation of a 9-membered lactone from an (R)-ester. The diastereomeric