Synthesis of 6??amino??2??aryl??1, 2??dihydro??3H??pyrido [2, 3??d] pyrimidin??4??one derivatives

A Monge, V Martinez??Merino, MA Simon…

Index: Monge; Martinez-Merino; Simon; Sanmartin Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 6 p. 1545 - 1549

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Citation Number: 8

Abstract

Abstract This paper reports the synthesis of new pyrido [2, 3-d] pyrimidin-4-one derivatives as diuretic agents. Starting with 1, 2-dihydro-5-nitro-2-oxo-3-pyridinecarboxylic acid 1, ethyl 2-ethoxy-5-nitro-3-pyridincarboxylate 4 was obtained. Compound 4 reacts with ammonia, methylamine or S-methylpseudothiourea to give the respective 2-amino-5-nitro-3- pyridinecarboxamide derivatives 5 and 6 or 2-methylthio-6-nitro-3H-pyrido [2, 3-d] ...