Convenient acylative dealkylation of tertiary amines

…, KA Kumar, R Duddu, T Axenrod, R Dai…

Index: Dave, Paritosh R.; Kumar, Kaipenchery A.; Duddu, Rajagopal; Axenrod, Theodore; Dai, Rongji; Das, Kajal K.; Guan, Xiao-Pei; Sun, Jianguang; Trivedi, Nirupam J.; Gilardi, Richard D. Journal of Organic Chemistry, 2000 , vol. 65, # 4 p. 1207 - 1209

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Citation Number: 26

Abstract

Protecting groups in the form of N-alkyl or N-aryl substituents hold a key position in heterocyclic chemistry in that selected groups on nitrogen frequently make possible the synthesis of ring compounds, which are otherwise inaccessible. Bulky N-protecting groups often provide control over the reaction pathway and heterocycle formation through Mannich condensations1 and Gaertner cyclizations, 2 to cite two examples. The versatility of this ...